Premenstrual syndrome (PMS) can involve a wide range of physical, emotional, and behavioral symptoms that occur during the menstrual cycle. Common symptoms include mood changes, irritability, fatigue, cramps, and discomfort. Researchers have investigated numerous supplements for their ability to support comfort, mood, and wellbeing during the premenstrual period. The supplements below are ranked according to the strength of the evidence and their expected impact on PMS symptoms.