Saffron

Reduces symptoms of depression with strong effects in clinical studies, though broader replication is needed. 1, 2, 3

Reduces premenstrual symptoms, including mood changes and discomfort, with moderate effects in clinical studies. 4, 5

Leads to small improvements in sleep quality, with modest and inconsistent effects. 6, 7, 8

Leads to small reductions in anxiety and stress, with limited and variable evidence. 9