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All proven supplements ranked for:

Mood & Depression

Mood influences emotional wellbeing, motivation, relationships, and overall quality of life. Low mood and depressive symptoms can arise from a complex interaction of biological, psychological, and lifestyle factors. Researchers have investigated numerous supplements for their potential role in supporting mood and emotional wellbeing. The supplements below are ranked according to the strength of the evidence and their expected impact on mood and depression-related outcomes.

XP combines how reliable the research is with how much difference it usually makes. Read more.

Reliable Impact

Limited Impact

Moderate Impact

High Impact

Curcumin

A bioactive compound found in turmeric, a spice derived from the root of the Curcuma longa plant

Goal Impact

70

XP

Saffron

Saffron is a spice harvested from the dried stigmas of the Crocus sativus flower

Goal Impact

70

XP

Creatine

Creatine is a natural compound found in muscles and in foods like red meat and fish

Goal Impact

50

XP

Probiotics

Live microorganisms found in fermented foods and supplements that are part of the gut microbiota

Goal Impact

30

XP

Magnesium

Magnesium is a mineral found in nuts, seeds, whole grains, and leafy greens

Goal Impact

30

XP

Omega-3

Omega-3 fatty acids are essential fats naturally found in fatty fish like salmon and mackerel

Goal Impact

30

XP

Vitamin D

Vitamin D is a fat-soluble vitamin made in the skin from sunlight and also present in oily fish

Goal Impact

30

XP

Ashwagandha

Ashwagandha is a traditional herb sourced from the root of the ashwagandha plant

Goal Impact

30

XP

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